S100β is a target protein of neurocalcin δ, an abundant isoform in glial cells
نویسندگان
چکیده
منابع مشابه
Brain lipid-binding protein is a direct target of Notch signaling in radial glial cells.
Radial glia function during CNS development both as neural progenitors and as a scaffolding supporting neuronal migration. To elucidate pathways involved in these functions, we mapped in vivo the promoter for Blbp, a radial glial gene. We show here that a binding site for the Notch effector CBF1 is essential for all Blbp transcription in radial glia, and that BLBP expression is significantly re...
متن کاملIslet Amyloid Polypeptide is not a Target Antigen for CD8+ T-Cells in Type 2 Diabetes
Background: Type 2 diabetes (T2D) is a chronic metabolic disorder in which beta-cells are destroyed. The islet amyloid polypeptide (IAPP) produced by beta-cells has been reported to influence beta-cell destruction. Objective: To evaluate if IAPP can act as an autoantigen and therefore, to see if CD8 + T-cells specific for this protein might be present in T2D patients. Methods: Peripheral blood ...
متن کاملPlasma Glial Fibrillary Acidic Protein, D-Dimer and S100β Protein: A Panel for Differential Diagnosis of Acute Stroke
Objectives: To explore the diagnostic utility of glial fibrillary acidic protein (GFAP), S100β protein and dDimer for differentiation between cases of acute stroke compared to CT findings as a gold-standard diagnostic modality. Patients & Methods: The study included 80 patients; 51 males and 29 females with mean age of 49.6±6.8 years. Mean time lapsed since occurrence of symptoms till sampling ...
متن کاملSerum Levels of Glial Fibrillaryacidic Protein in Meningioma
Background: Glial fibrillaryacidic protein (GFAP), an intermediate filament protein, is mainly expressed by astrocytes, but some other cells like enteric glia and non-myelinating Schwann cells can also express GFAP. GFAP elevation has been reported in some types of meningioma and malignant brain tumors. In the present study, we analyzed the association between serum levels of GFAP with meningio...
متن کاملA Toc75-like protein import channel is abundant in chloroplasts.
Chloroplasts import post-translationally most of their constituent polypeptides via two distinct translocon units located in the outer and inner envelope. The protein import channel of the translocon of the outer envelope of chloroplasts, Toc75, is the most abundant protein in that membrane. We identify a novel Toc75 homologous protein, atToc75-V, a prominent protein that is clearly localized i...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1995
ISSN: 0264-6021,1470-8728
DOI: 10.1042/bj3060551